• Affiliate Professor, Global Health
  • Principal Staff Scientist, Fred Hutchinson Cancer Research Center

Fred Hutchinson Cancer Research Center
1100 Fairview Ave N
Seattle, WA 98109
United States

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Dr. Holte's primary interests include biostatistics and biomathematics and in particular, the interplay between the two. Her specific interests involve identifying, developing and evaluating statistical approaches that can be used in combination with mathematical models defined by differential equations for viral and immune system dynamics. Dr. Holte also serve as Director for the CFAR Biometrics Core.

Dr. Holte specializes in the analysis of nonlinear time series data and estimation and inference for parameters in differential equations models. She's the PI of an R21 designed to create a large database of individuals enrolled in studies during acute HIV infection. This requires careful database design. Her ultimate goal is to have many groups contribute to the database so that it is possible to evaluate a large cohort for prevalence and associates of Post-Treatment Control of HIV infection. 

  • PhD (University of Oregon)
  • MA (University of Oregon)
  • BA (University of Minnesota)
Country Affiliations 
Health Topics 
  • Biostatistics
DGH Centers, Programs and Initiatives and Affiliated Organizations 

Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang L, Whitcomb JM, Hellmann NS, Richman DD. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med. 2002 Aug 8;347(6):385-94.

Holte S, Frenkel L, Melvin A, Mullins J. Density Dependant Decay in HIV-1 Dynamics. JAIDS 2006 41(3):266-76.

Holte S, Randolph T, Ding J, Tien J, McClelland R.S, Baeten J, Overbaugh J. Efficient use of longitudinal CD4 counts and viral load measures in survival analysis. Statistics in Medicine. 2012 Aug 30;31(19):2086-97. PMID: 22415871

Maenza J, Tapia K, Holte S, Stekler J, Stevens CE, Mullins JI, Collier AC. How often does treatment of primary HIV lead to post-treatment control? Antiviral Therapy 2015 Apr 23. Epub ahead of print.

Holte SE, Lee EK, Mei Y. Symmetirc Directional False Discovery Rate Control. Stat Methodol. 2016 Dec;33:71-82.