The effect of HIV exposure and infection on immunity to TB in children
The proposed study aims to determine the effect of HIV exposure on trained immunity in BCG-vaccinated infants (Aim 1), test the hypothesis that maternal HIV exposure and infant HIV infection modifies anti-mycobacterial immunity via epigenetic reprogramming of innate immune cells (Aim 2), and determine prevalence, predictors, and effect (on TB infection and disease) of anti-mycobacterial immunity in HIV+ children (Aim 3).
Active Dates
01/01/2019 to 12/31/2023
Faculty Involved
Health Topics